Current Issue : January - March Volume : 2013 Issue Number : 1 Articles : 5 Articles
Leucine stimulates tissue protein synthesis and may also attenuate adiposity by\r\nincreasing fatty acid oxidation and mitochondrial biogenesis in muscle and adipocytes.\r\nAccordingly, the effects of a nutraceutical containing 2.25 g leucine and 30 mg pyridoxine\r\n(Vitamin B6) (NuFit active blend) were tested in cell culture and in a clinical trial. 3T3L1\r\nadipocytes were treated with leucine (0.25 mM or 0.5 mM) and/or Pyridoxal Phosphate\r\n(PLP) (50 nM or 100 nM) for 48 h. For the clinical trial, twenty overweight or obese\r\nsubjects received the NuFit active blend or placebo three times/day for 4 weeks without\r\nenergy restriction. Leucine decreased fatty acid synthase (FAS) expression and triglyceride\r\ncontent in adipocytes, and PLP addition significantly augmented this effect. Administration\r\nof NuFit active blend in the clinical trial increased fat oxidation by 33.6 g/day (p < 0.04),\r\ndecreased respiratory quotient, improved HOMAIR, reduced oxidative and inflammatory\r\nbiomarkers (plasma MDA, 8-isoprostane-F2a, TNF-a, C-reactive protein), and increased\r\nthe anti-inflammatory marker adiponectin. These data indicate that the NuFit active blend\r\nsignificantly increased fat oxidation and insulin sensitivity, and reduced oxidative and\r\ninflammatory stress. Therefore, the NuFit active blend appears to be a useful nutraceutical\r\nin the management of obesity and associated co-morbidities....
As proper nourishment is a growing concern with increasing world populations, sustainable sources of\r\nnutritional value are needed. Due to the diverse nutritional components algae can produce and concentrate, along\r\nwith their simple and rapid growth characteristics, these autotrophic organisms are exceedingly desired for use in\r\nnutraceuticals and nutritional supplements. Many types of algae have documented health benefits from strengthening\r\nthe immune system to fighting cancer and heart disease. Information presented in this article was mined from\r\nquality, peer-reviewed published literature, technical reports and books. This review evaluates the use of Chlorella,\r\nDunaliella, Haematococcus, Aphanizomenon, and Spirulina as nutraceuticals and nutritional supplements, in terms\r\nof production, nutritional components, and documented health benefits....
Cardiovascular disease (CVD) is now the leading cause of death globally and is a growing health concern. Dietary factors are\r\nimportant in the pathogenesis of CVD and may to a large degree determine CVD risk, but have been less extensively investigated.\r\nFunctional foods are those that are thought to have physiological benefits and/or reduce the risk of chronic disease beyond their\r\nbasic nutritional functions. The food industry has started to market products labelled as ââ?¬Å?functional foods.ââ?¬Â Although many review\r\narticles have focused on individual dietary variables as determinants of CVD that can be modified to reduce the risk of CVD, the\r\naim of this current paper was to examine the impact of functional foods in relation to the development and progression of CVD.\r\nEpidemiologic studies have demonstrated the association between certain dietary patterns and cardiovascular health. Research into\r\nthe cardio-protective potential of their dietary components might support the development of functional foods and nutraceuticals.\r\nThis paper will also compare the effect of individual bioactive dietary compounds with the effect of some dietary patterns in terms\r\nof their cardiovascular protection....
Diabetes Mellitus is spreading worldwide as an epidemic characterized by the cessation in the ability of the tissues to utilize carbohydrates. It occurs throughout the world, but the incidence of occurrence is more common in developing countries due to the trends of urbanization and lifestyle changes, especially switching to a "Western-style" diet. Adequate nourishment is an essential prerequisite to human health and productivity. It has long been suggested that diet is crucial in the development of insulin resistance although conclusive human data is lacking. However, some detractors of “modern” innovations in the diet have relied on legumes especially beans for sustenance and health augmentation. Red Kidney beans (Phaseolus vulgaris L.) have been somewhat overlooked and played an integral part of the development of many cultures which are intricately woven into the fabric of human history. Therefore, keeping in view the present scenario, an evaluation and enhancement of nutritional quality of kidney beans after using appropriate household practices- hot water blanching and to explore the acceptability of conventional recipe such-Missi Roti. Nutrients, antinutrients and antioxidants estimations were done in native and processed form of variety by using standardized procedure (AOAC). Organoleptic evaluation was conduct on the basis of 9 point hedonic method by 15 semi-trained panel members. Data obtained was subjected to the analysis of Mean and Standard Deviation....
Obesity and its related metabolic abnormalities, including insulin resistance,\r\nalterations in the insulin-like growth factor-1 (IGF-1)/IGF-1 receptor (IGF-1R) axis, and\r\nthe state of chronic inflammation, increase the risk of colorectal cancer (CRC) and\r\nhepatocellular carcinoma (HCC). However, these findings also indicate that the metabolic\r\ndisorders caused by obesity might be effective targets to prevent the development of\r\nCRC and HCC in obese individuals. Green tea catechins (GTCs) possess anticancer and\r\nchemopreventive properties against cancer in various organs, including the colorectum and\r\nliver. GTCs have also been known to exert anti-obesity, antidiabetic, and anti-inflammatory\r\neffects, indicating that GTCs might be useful for the prevention of obesity-associated\r\ncolorectal and liver carcinogenesis. Further, branched-chain amino acids (BCAA), which\r\nimprove protein malnutrition and prevent progressive hepatic failure in patients with\r\nchronic liver diseases, might be also effective for the suppression of obesity-related\r\ncarcinogenesis because oral supplementation with BCAA reduces the risk of HCC in obese\r\ncirrhotic patients. BCAA shows these beneficial effects because they can improve insulin\r\nresistance. Here, we review the detailed relationship between metabolic abnormalities and\r\nthe development of CRC and HCC. We also review evidence, especially that based on our\r\nbasic and clinical research using GTCs and BCAA, which indicates that targeting\r\nmetabolic abnormalities by either pharmaceutical or nutritional intervention may be an\r\neffective strategy to prevent the development of CRC and HCC in obese individuals....
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